First Issue
When we closely look at the Top 10 risk above again, most (except smoking & inactivity) can be reversed or at least improved by lifestyle intervention ie IF + ketogenic diet!
Hence, we can hypothesize that IF + ketogenic/low carb diet will prevent development of CHD in the future!.
We are waiting for more definitive studies to prove that.. meanwhile, as aptly said by Prof Tim Noakes:
Second Issue
Concerning raised Total Cholesterol & LDL, which we commonly see in those on IF/keto. Should they take statins? Let's look at recent review article by Diamond et al, 2022
SUMMARY AND CONCLUSION (from the authors)
We have addressed concerns regarding high LDL-C in
individuals on an LCD, which began 5 decades ago and persist to the present
day. Our review has evaluated whether these concerns are justified based on
three levels of analysis.
First, critics of the LCD have focused on how
the diet may increase LDL-C. However, there is a substantial literature
demonstrating that LDL-C is of limited utility as a CVD risk factor.
Second, we reviewed the literature on LCD
improvements in CVD risk factors which are superior to LDL-C, such as IR,
hypertension, hyperglycemia, LDL particle subtypes, and metabolic syndrome.
Third, we summarized RCTs which demonstrate
that individuals with high LDL-C and an LCD-like lipid profile (low TGs
and high HDL-C), had a low rate of coronary events under nontreatment
conditions and derived no CVD benefit from statin therapy. Therefore,
our review of the literature provides support for the conclusion that LDL-C
reduction with a statin would not provide any benefit in primary or secondary
prevention of CVD for an individual on an LCD.
-The choice is yours to decide on your own health
journey-
